|
Background
|
BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
|
Background
References
|
- Cartron, P.F., et al., Mol. Cell. Biol. 23(13):4701-4712 (2003).
- Mikhailov, V., et al., J. Biol. Chem. 278(7):5367-5376 (2003).
- Werner, A.B., et al., J. Biol. Chem. 277(25):22781-22788 (2002).
- Bellosillo, B., et al., Blood 100(5):1810-1816 (2002).
- Grutkoski, P.S., et al., Shock 17(1):47-54 (2002).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
