|
Background
|
Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.
|
Background
References
|
- Denisov, A.Y., et al., J. Biol. Chem. 278(23):21124-21128 (2003).
- Hinds, M.G., et al., EMBO J. 22(7):1497-1507 (2003).
- Middleton, G., et al., Development 128(3):447-457 (2001).
- Ross, A.J., et al., Nat. Genet. 18(3):251-256 (1998).
- Gibson, L., et al., Oncogene 13(4):665-675 (1996).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
