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Background
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Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
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Background
References
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- Chen, D., et al., Proc. Natl. Acad. Sci. U.S.A. 101(5):1235-1240 (2004).
- Luciano, F., et al., Oncogene 22(43):6785-6793 (2003).
- Sunters, A., et al., J. Biol. Chem. 278(50):49795-49805 (2003).
- Reginato, M.J., et al., Nat. Cell Biol. 5(8):733-740 (2003).
- Chen, D., et al., EMBO J. 21(24):6801-6810 (2002).
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