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Background
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The Mcl-1 protein belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.
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Background
References
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- Crossley, L.J., J. Leukoc. Biol. 74(4):583-592 (2003).
- Kotelkin, A., et al., J. Virol. 77(17):9156-9172 (2003).
- Erwert, R.D., et al., Microb. Pathog. 35(2):87-93 (2003).
- Liu, H., et al., Blood 102(1):344-352 (2003).
- Nijhawan, D., et al., Genes Dev. 17(12):1475-1486 (2003).
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