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Background
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PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
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Background
References
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- Liu, F.T., et al., Biochem. Biophys. Res. Commun. 310(3):956-962 (2003).
- Hoque, M.O., et al., Cancer Lett. 199(1):75-81 (2003).
- Yu, J., et al., Proc. Natl. Acad. Sci. U.S.A. 100(4):1931-1936 (2003).
- Han, J., et al., Proc. Natl. Acad. Sci. U.S.A. 98(20):11318-11323 (2001).
- Nakano, K., et al., Mol. Cell 7(3):683-694 (2001).
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