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Background
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DPF2 is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. DPF2 gene is considered a causal candidate for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
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Background
References
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- Olsen,J.V.,Cell 127 (3), 635-648 (2006)
- Beausoleil,S.A.,Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
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