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Background
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DPF2 is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. The DPF2 gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
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Background
References
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- Ninkina, N.N., et al., Mamm. Genome 12(11):862-866 (2001).
- Gabig, T.G., et al., Mamm. Genome 9(8):660-665 (1998).
- Guru, S.C., et al., Genome Res. 7(7):725-735 (1997).
- Chestkov, A.V., et al., Genomics 36(1):174-177 (1996).
- Gabig, T.G., et al., J. Biol. Chem. 269(47):29515-29519 (1994).
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