|
Background
|
CDH1 is a classical cadherin from the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization.
|
Background
References
|
- Mansouri,A., Differentiation 38 (1), 67-71 (1988)
- Knudsen,K.A. J. Cell Biol. 118 (3), 671-679 (1992)
- Hsu,Y.M., Cancer Res. 67 (22), 11064-11073 (2007)
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
