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Background
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ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
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Background
References
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- Tellier,E., J. Cell. Physiol. 214 (3), 687-693 (2008)
- Takamune,Y., Biochem. Biophys. Res. Commun. 365 (2), 393-398 (2008)
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Order Information
List Price (USA): $235.00/0.1mg
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