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Background
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Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. GABARAP is GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
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Background
References
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- Nemos, C., et al., Brain Res. Mol. Brain Res. 119(2):216-219 (2003).
- Stangler, T., et al., J. Biol. Chem. 277(16):13363-13366 (2002).
- Knight, D., et al., J. Biol. Chem. 277(7):5556-5561 (2002).
- Tanida, I., et al., J. Biol. Chem. 277(16):13739-13744 (2002).
- Harris, R., et al., J. Biomol. NMR 21(2):185-186 (2001).
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