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Background
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DRAM is regulated as part of the p53 tumor suppressor pathway. It is a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this protein is associated with various tumors.
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Background
References
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- Kerley-Hamilton,J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007)
- Crighton,D., Autophagy 3 (1), 72-74 (2007)
- Crighton,D., Cell 126 (1), 121-134 (2006)
- Green,D.R., Cell 126 (1), 30-32 (2006)
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