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Background
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UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving the UVAG gene are associated with left-right axis malformation and mutations in the gene have been associated with colon cancer.
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Background
References
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- Liang,C., et al. Nat. Cell Biol. 8 (7), 688-699 (2006)
- Ionov,Y., et al. Oncogene 23 (3), 639-645 (2004)
- Goi,T., et al. Surg. Today 33 (9), 702-706 (2003)
- Iida,A., et al. Hum. Genet. 106 (3), 277-287 (2000)
- Perelman,B., et al. Genomics 41 (3), 397-405 (1997)
- Bekri,S., et al. Cytogenet. Cell Genet. 79 (1-2), 125-131 (1997)
- Teitz,T., et al. Gene 87 (2), 295-298 (1990)
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