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Background
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BCCIP was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21.
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Background
References
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- Lu, H., et al., Mol. Cell. Biol. 25(5):1949-1957 (2005).
- Meng, X., et al., Cell Cycle 3(3):343-348 (2004).
- Robson, M., et al., J. Med. Genet. 39(2):126-128 (2002).
- Armakolas, A., et al., Hum. Mutat. 19(1):81-82 (2002).
- Liu, J., et al., Oncogene 20(3):336-345 (2001).
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