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Background
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BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors
bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension.
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Background
References
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- Pouliot, F., et al., Cancer Res. 63(2):277-281 (2003).
- Nishihara, A., et al., Mol. Biol. Cell 13(9):3055-3063 (2002).
- Humbert, M., et al., Eur Respir J 20(3):518-523 (2002).
- Vitt, U.A., et al., Biol. Reprod. 67(2):473-480 (2002).
- Nohe, A., et al., J. Biol. Chem. 277(7):5330-5338 (2002).
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