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Background
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CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
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Background
References
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- Kunkel, E.J., et al., J. Clin. Invest. 111(7):1001-1010 (2003).
- Fra, A.M., et al., J. Immunol. 170(5):2279-2282 (2003).
- Soler, D., et al., Blood 101(5):1677-1682 (2003).
- Nibbs, R.J., et al., Am. J. Pathol. 158(3):867-877 (2001).
- Bonini, J.A., et al., DNA Cell Biol. 16(10):1249-1256 (1997).
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List Price (USA): $235.00/0.1mg
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