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Background
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EDD is a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22, a locus disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
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Background
References
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- Clancy, J.L., et al., Oncogene 22(32):5070-5081 (2003).
- Henderson, M.J., et al., J. Biol. Chem. 277(29):26468-26478 (2002).
- Honda, Y., et al., J. Biol. Chem. 277(5):3599-3605 (2002).
- Callaghan, M.J., et al., Oncogene 17(26):3479-3491 (1998).
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List Price (USA): $235.00/0.1mg
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