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Background
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L6 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to function in the E6/E6-ap-induced ubiquitination of p53.
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Background
References
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- Kumar, S., et al., J. Biol. Chem. 272(21):13548-13554 (1997).
- Ardley, H.C., et al., Cytogenet. Cell Genet. 89 (1-2), 137-140 (2000).
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