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Background
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2N is a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.
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Background
References
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- Bothos, J., et al., Oncogene 22(46):7101-7107 (2003).
- McKenna, S., et al., J. Biol. Chem. 278(15):13151-13158 (2003).
- Hofmann, R.M., et al., Cell 96(5):645-653 (1999).
- Yamaguchi, T., et al., J. Biochem. 120(3):494-497 (1996).
- Ashley, C., et al., Gene 285 (1-2), 183-191 (2002).
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