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Background
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The UBL4 gene lies in a ubiquitiously transcribed region on the X chromosome approximately 40 kb downstream of glucose-6-phosphate dehydrogenase (G6PD).1 The UBL4 gene, which encodes for a 157 amino acid protein, is consistent with the characteristics of a housekeeping gene, since transcripts are detected a multiple cell types, and the protomoter region is rich in GC sequences and lacks signals such as TATA and CAT boxes. The UBL4 protein bears strong similarity in its 72 N-terminal amino acids to ubiquitin. In the middle of the C-terminus moiety of the UBL4 protein, similarities to the thyroglobulin hormonogenic site, the sequence that surrounds the tyrosines that will form thyroxine, have been demonstrated.2 It has been inferred from these data that the UBL4 protein plays an important role in essential cellular functions.
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Background
References
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- Chen, E.Y., et al., Hum. Mol. Genet. 5(5):659-668 (1996).
- Toniolo, D., et al., Proc. Natl. Acad. Sci. U.S.A. 85(3):851-855 (1988).
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