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Background
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ARL1 belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
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Background
References
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- Hong, J.X., et al., J. Biol. Chem. 273(25):15872-15876 (1998).
- Zhang, G.F., et al., J. Biol. Chem. 270(1):21-24 (1995).
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List Price (USA): $99.00/0.1mg
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