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Background
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GGA3 is a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins.
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Background
References
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- Wakasugi, M., et al., Biochem. Biophys. Res. Commun. 306(3):687-692 (2003).
- Misra, S., et al., Nature 415(6874):933-937 (2002).
- Puertollano, R., et al., Science 292(5522):1712-1716 (2001).
- Takatsu, H., et al., Biochem. Biophys. Res. Commun. 271(3):719-725 (2000).
- Dell'Angelica, E.C., et al., J. Cell Biol. 149(1):81-94 (2000).
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