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Background
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Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. GPLD1 is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane
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Background
References
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- Hoener, M.C., et al., Eur. J. Biochem. 206(3):747-757 (1992).
- Tsang, T.C., et al., FASEB J. 6, A1922-A1922 (1992).
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