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Background
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RNP2 a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1.
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Background
References
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- Kelleher, D.J., et al., Mol. Cell 12(1):101-111 (2003).
- Fu, J., et al., J. Biol. Chem. 275(6):3984-3990 (2000).
- Loffler, C., et al., Hum. Genet. 87(2):221-222 (1991).
- Crimaudo, C., et al., EMBO J. 6(1):75-82 (1987).
- Stoffel, M., et al., Hum. Mol. Genet. 1 (8), 656 (1992).
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