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Background
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There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. MGAT3 (N-acetylglucosaminyltransferase III) transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Expression of this gene may be controlled by a multiple-promoter system.
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Background
References
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- Shibukawa, Y., et al., J. Biol. Chem. 278(5):3197-3203 (2003).
- Koyama, N., et al., Eur. J. Biochem. 238(3):853-861 (1996).
- Kim, Y.J., et al., Gene 170(2):281-283 (1996).
- Ihara, Y., et al., J. Biochem. 113(6):692-698 (1993).
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