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Background
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FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.
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Background
References
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- Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
- Soltis, D.A., et al., Arch. Biochem. Biophys. 316(2):713-723 (1995).
- Jiang, G., et al., J. Biol. Chem. 268(17):12818-12824 (1993).
- Robinson, G.W., et al., Mol. Cell. Biol. 13(5):2706-2717 (1993).
- Summers, C., et al., Gene 136 (1-2Che), 185-192 (1993).
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List Price (USA): $235.00/0.1mg
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