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Background
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VNN2 is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils.
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Background
References
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- Sasaki, H., et al., Cancer Sci. 94(9):809-813 (2003).
- Takeda, Y., et al., Exp. Cell Res. 286(2):199-208 (2003).
- Sendo, D., et al., Immunobiology 207(3):217-221 (2003).
- Martin, F., et al., Immunogenetics 53(4):296-306 (2001).
- Suzuki, K., et al., J. Immunol. 162(7):4277-4284 (1999).
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List Price (USA): $99.00/0.1mg
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