|
Background
|
Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock protein gene expression in cells exposed to elevated temperature and other stress conditions. In response to stress, HSF1 acquires DNA-binding ability and localizes to nuclear stress granules. SUMO modification of HSF1 converts HSF1 to the DNA-binding form. HSF1 colocalizes with SUMO-1 in nuclear stress granules, which is prevented by mutation of the HSF1 lysine targeted for sumoylation.
|
Background
References
|
- Hilgarth, et al., Biochem Biophys Res Commun. 2003 Mar 28;303(1):196-200.
- He, H., et al., J. Biol. Chem. 278(37):35465-35475 (2003).
- Wang, X., et al., Mol. Cell. Biol. 23(17):6013-6026 (2003).
- Ignatenko, N.A., et al., Exp. Cell Res. 288(1):1-8 (2003).
- Soncin, F., et al., Biochem. Biophys. Res. Commun. 303(2):700-706 (2003).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
