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Background
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HSF2 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. The protein is found as a DNA-binding homotrimer in stressed or heat shocked cells, and otherwise found as a homodimer. HSF2 is cytoplasmic during normal growth and moves to the nucleus upon activation. Sumoylation of HSF2 hinders HSF2 DNA-binding activity, without affecting its oligomerization, and is an example of negative regulation of gene expression via sumoylation.
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Background
References
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- He, H., et al., J. Biol. Chem. 278(37):35465-35475 (2003).
- Nykanen, P., et al., Cell Stress Chaperones 6(4):377-385 (2001).
- Sarge, K.D., et al., Genes Dev. 5(10):1902-1911 (1991).
- Schuetz, T.J., et al., Proc. Natl. Acad. Sci. U.S.A. 88(16):6911-6915 (1991).
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