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Background
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RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
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Background
References
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- Bischoff, F.R., et al., Proc. Natl. Acad. Sci. U.S.A. 92(5):1749-1753 (1995).
- Bischoff, F.R., et al., Proc. Natl. Acad. Sci. U.S.A. 91(7):2587-2591 (1994).
- Matunis, M.J., et al., J. Cell Biol. 135 (6 Pt 1), 1457-1470 (1996).
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