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Background
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NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
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Background
References
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- Miskolci, V., et al., Arch. Biochem. Biophys. 417(1):44-52 (2003).
- Kim, Y.S., et al., J. Biol. Chem. 278(31):28462-28469 (2003).
- Parcellier, A., et al., Mol. Cell. Biol. 23(16):5790-5802 (2003).
- Takada, Y., et al., J. Biol. Chem. 278(26):24233-24241 (2003).
- Place, R.F., et al., J. Cell. Physiol. 195(3):470-478 (2003).
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