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Background
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The gene for AP-1 is the putative transforming gene of avian sarcoma virus 17. AP-1 is highly similar to the viral protein, and interacts directly with specific target DNA sequences to regulate gene expression. The AP-1 gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. AP-1 dimer activity is downregulated by SUMO-1, SUMO-2, and SUMO-3.
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Background
References
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- Bossis, et al., Mol Cell Biol. 2005 Aug;25(16):6964-79.
- Perez-Sala, D., et al., J. Biol. Chem. 278(51):51251-51260 (2003).
- Yang, H., et al., J. Biol. Chem. 278(51):50887-50896 (2003).
- Toborek, M., et al., J. Neurochem. 84(1):169-179 (2003).
- Wang, Y.N., et al., J. Biol. Chem. 278(46):45848-45857 (2003).
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