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Background
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EZH1 encodes a protein of 747 amino acids that displays 55% amino acid identity overall with the Drosophila homolog.1 The strong sequence conservation suggested potential roles for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that preserve heterochromatin stability. EZH1 is expressed as 2 major transcripts in all adult and fetal human tissues evaluated.. Analysis of an EZH1 cDNA revealed an unusual splicing event involving EZH1 and a tandemly linked gene GPR2 and suggested a potential mechanism for modifying the EZH1 protein in the conserved C-terminal domain. The GPR2 gene maps to 17q21.1-q21.3 in the vicinity of the BRCA1 gene.
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Background
References
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- Ogawa, M., et al., Biochim. Biophys. Acta 1395(2):151-158 (1998).
- Abel, K.J., et al., Genomics 37(2):161-171 (1996).
- Friedman, L.S., et al., Genomics 25(1):256-263 (1995).
- Osborne-Lawrence, S., et al., Genomics 25(1):248-255 (1995).
- Brody, L.C., et al., Genomics 25(1):238-247 (1995).
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