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Background
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EZH2, SUZ12, and EED form a complex that methylates nucleosomal histone H3 at Lys27. EZH2 contains a SET domain, a signature motif for all known histone lysine methyltransferases except the H3-K79 methyltransferase DOT1, and is therefore likely to be the catalytic subunit. Consequently, EZH2 is thought to regulate gene expression by controlling chromatin structure. Several lines of evidence suggested a critical role for the EZH2 protein during normal and perturbed development of the hematopoietic and central nervous systems. The EZH2 protein has been shown to associate with the VAV1 protooncoprotein and with the XNP protein, the product of a gene associated with mental retardation. Additionally, due to mapping of EZH2 to the 7q35-q36 chromosomal region associated with myeloid disorders, this protein is suggested to participate in the genetic events triggering myeloid leukemia.
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Background
References
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- Cardoso, C., et al., Hum. Mol. Genet. 7(4):679-684 (1998).
- Laible, G., et al., EMBO J. 16(11):3219-3232 (1997).
- Hobert, O., et al., Mol. Cell. Biol. 16(6):3066-3073 (1996).
- Chen, H., et al., Genomics 38(1):30-37 (1996).
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