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Background
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BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.
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Background
References
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- Smith, K.S., et al., Mol. Cell 12(2):393-400 (2003).
- Xia, Z.B., et al., Proc. Natl. Acad. Sci. U.S.A. 100(14):8342-8347 (2003).
- Itahana, K., et al., Mol. Cell. Biol. 23(1):389-401 (2003).
- Dimri, G.P., et al., Cancer Res. 62(16):4736-4745 (2002).
- Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).
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