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Background
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The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.
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Background
References
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- Megonigal, M.D., et al., Proc. Natl. Acad. Sci. U.S.A. 97(6):2814-2819 (2000).
- Pegram, L.D., et al., Blood 96(13):4360-4362 (2000).
- Sano, K., et al., Blood 95(3):1066-1068 (2000).
- Cui, X., et al., Nat. Genet. 18(4):331-337 (1998).
- Nilson, I., et al., Br. J. Haematol. 93(4):966-972 (1996).
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