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Background
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AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.
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Background
References
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- Steuber,H.,J. Mol. Biol. 379 (5), 991-1016 (2008)
- Gleissner,C.A.,Arterioscler. Thromb. Vasc. Biol. 28 (6), 1137-1143 (2008)
- Grundmann,U.,DNA Cell Biol. 9 (3), 149-157 (1990)
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