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Background
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GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45A gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.
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Background
References
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- Li,L.S., J. Biol. Chem. 283 (31), 21394-21403 (2008)
- Al-Romaih,K., Neoplasia 10 (5), 471-480 (2008)
- Zhu,Q.S., Cancer Res. 68 (8), 2895-2903 (2008)
- Kearsey,J.M., Oncogene 11 (9), 1675-1683 (1995)
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List Price (USA): $235.00/0.1mg
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