|
Background
|
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The gene for this protein is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. The gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
|
Background
References
|
- Lusic, M., et al., EMBO J. 22(24):6550-6561 (2003).
- Deng, L., et al., Virology 289(2):312-326 (2001).
- Deng, L., et al., Virology 277(2):278-295 (2000).
- El Kharroubi, A., et al., Mol. Cell. Biol. 18(5):2535-2544 (1998).
- Albig, W., et al., Hum. Genet. 101(3):284-294 (1997).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
