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Background
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AKT1belongs to the protein kinase C superfamily. This kinase is activated bythe Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis.
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Background
References
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- Isagawa, T., et al., Mol. Carcinog. 43(1):1-12 (2005).
- Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004).
- Bourguignon, L.Y., et al., J. Biol. Chem. 279(28):29654-29669 (2004).
- Owen, D., et al., J. Biol. Chem. 278(50):50578-50587 (2003).
- Takahashi, M., et al., J. Biochem. 133(2):181-187 (2003).
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