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Background
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Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. Bid induces ICE-like proteases and apoptosis. It is a
mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the major proteolytic product p15 Bid translocates to mitochondria where it triggers cytochrome c release.
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Background
References
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- J. Biol. Chem. 280 (46), 38271-38275 (2005)
- J. Biol. Chem. 280 (13), 12486-12493 (2005)
- J. Biol. Chem. 279 (28), 28954-28960 (2004)
- J. Biol. Chem. 279 (27), 28771-28780 (2004)
- J. Biol. Chem. 279 (4), 2846-2855 (2004)
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List Price (USA): $235.00/0.1mg
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