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Background
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ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
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Background
References
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- Provinciali, M., et al., Int. J. Cancer 115(1):36-45 (2005).
- Yee, L.D., et al., J. Nutr. 135(5):983-988 (2005).
- Beckers, J., et al., Int. J. Cancer 114(4):590-597 (2005).
- Brandt, B., et al., Biochem. Biophys. Res. Commun. 329(1):318-323 (2005).
- Ghatak, S., et al., J. Biol. Chem. 280(10):8875-8883 (2005).
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