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Background
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FADD is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
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Background
References
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- Zhang J., Winoto A. Mol. Cell. Biol. 16:2756-2763(1996).
- Hsu H., et al. Cell 84:299-308(1996).
- Jeong E.-J., et al. J. Biol. Chem. 274:16337-16342(1999).
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