|
Background
|
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
|
Background
References
|
- Scott, S.A., et al., Leuk. Res. 28(12):1293-1301 (2004).
- Amini, S., et al., J. Biol. Chem. 279(44):46046-46056 (2004).
- Chen, T., et al., Cancer Res. 64(20):7412-7419 (2004).
- Sieburg, M., et al., J. Virol. 78(19):10399-10409 (2004).
- Giraud, S., et al., Oncogene 23(44):7391-7398 (2004).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
