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Background
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EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CPB (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
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Background
References
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- Finlan, L., et al., J. Biol. Chem. 279(47):49395-49405 (2004).
- Dornan, D., et al., Mol. Cell. Biol. 24(22):10083-10098 (2004).
- Jin, Y.H., et al., J. Biol. Chem. 279(28):29409-29417 (2004).
- Kung, A.L., et al., Cancer Cell 6(1):33-43 (2004).
- Chen, J., et al., Cell. Mol. Life Sci. 61(13):1675-1683 (2004).
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