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Background
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This gene is highly similar to the v-src gene of Rous
sarcoma virus. This proto-oncogene may play a role in the
regulation of embryonic development and cell growth. The protein
encoded by this gene is a tyrosine-protein kinase whose activity
can be inhibited by phosphorylation by c-SRC kinase. Mutations in
this gene could be involved in the malignant progression of colon
cancer. Two transcript variants encoding the same protein have been
found for this gene.
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Background
References
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- Chestukhin, A., et al., Proc. Natl. Acad. Sci. U.S.A. 100(8):4574-4579 (2003).
- Waizenegger, I., et al., Curr. Biol. 12(16):1368-1378 (2002).
- Chen, F., et al., J. Biol. Chem. 277(19):16775-16781 (2002).
- Hauf, S., et al., Science 293(5533):1320-1323 (2001).
- Zou, H., et al., Science 285(5426):418-422 (1999).
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