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Background
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Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.
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Background
References
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- Steinberg, M., et al., Blood 104(3):760-767 (2004).
- Wang, S., et al., World J. Gastroenterol. 10(12):1815-1818 (2004).
- Hayes, M.J., et al., Mol. Immunol. 41(4):457-468 (2004).
- Arndt, P.G., et al., J. Biol. Chem. 279(12):10883-10891 (2004).
- Ding, Y.B., et al., Zhonghua Yi Xue Za Zhi 84(4):290-293 (2004).
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