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Background
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RPS6KB1 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding the gene for RPS6KB1 and overexpression of this kinase are seen in some breast cancer cell lines.
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Background
References
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- Adem, C., et al., Genes Chromosomes Cancer 41(1):1-11 (2004).
- Suzuki, Y., et al., Genome Res. 14(9):1711-1718 (2004).
- Gomez-Cambronero, J., et al., Leuk. Res. 28(7):755-762 (2004).
- Raught, B., et al., EMBO J. 23(8):1761-1769 (2004).
- Miyakawa, M., et al., Endocr. J. 50(1):77-83 (2003).
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List Price (USA): $235.00/0.1mg
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