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Background
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PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.
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Background
References
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- Li, W., et al., J. Biol. Chem. 279(31):32824-32831 (2004).
- DerMardirossian, C., et al., Mol. Cell 15(1):117-127 (2004).
- Weber, D.S., et al., Circ. Res. 94(9):1219-1226 (2004).
- Balasenthil, S., et al., J. Biol. Chem. 279(2):1422-1428 (2004).
- Wu, R.F., et al., J. Virol. 78(2):779-789 (2004).
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