|
Background
|
PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
|
Background
References
|
- Cools, J., et al., Blood 103(7):2802-2805 (2004).
- Afink, G., et al., Biochem. Biophys. Res. Commun. 315(2):313-318 (2004).
- Zhu, H., et al., Mol. Genet. Metab. 81(2):127-132 (2004).
- Al-Ali, H.K., et al., Hematol. J. 5(1):55-60 (2004).
- Heinrich, M.C., et al., Science 299(5607):708-710 (2003).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
