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Background
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AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.
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Background
References
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- George, S., et al., Science 304(5675):1325-1328 (2004).
- Xu, X., et al., Oncol. Rep. 11(1):25-32 (2004).
- Shim, D., et al., Arch. Biochem. Biophys. 425(2):214-220 (2004).
- Li, X., et al., Gastroenterology 126(1):122-135 (2004).
- Vojtek, A.B., et al., Mol. Cell. Biol. 23(13):4417-4427 (2003).
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